If you need to send all outbound mail through another smtp server (example, if your ISP blocks your port 25 and you have no other way of sending mail) you can do so by editing your /etc/exim.conf and changing:
lookuphost:
driver = dnslookup
domains = ! +local_domains
ignore_target_hosts = 127.0.0.0/8
condition = "${perl{check_limits}}"
transport = remote_smtp
no_more
to
smart_route:
driver = manualroute
domains = ! +local_domains
ignore_target_hosts = 127.0.0.0/8
condition = "${perl{check_limits}}"
transport = remote_smtp
route_list = * smtp.yourisp.com
no_more
Where smtp.yourisp.com is the server you want to send your mail though.
Restart exim after making changes to your exim.conf