If you wish to have exim send an warning to your email users when their inbox is reaching it's limit, edit your /etc/exim.conf, find the virtual_localdelivery:, just after the line that begins with quota = add:
quota_warn_threshold = 80% quota_is_inclusive = false quota_warn_message = "\ To: $local_part@$domain\n\ Subject: Your mailbox\n\n\ This message was automatically created\n\ by mail delivery software.\n\n\ The size of your mailbox $local_part has exceeded \n\ a warning threshold of 80 percent\n\ of your maximum mailbox size.\n"
Save, exit, and restart exim.