20,21: FTP. Note that ftp will use a “random high port number” if the client is in PORT mode, so you may need to add a port range into your /etc/proftpd.conf file to allow ftp connections, eg:
PassivePorts 35000 35999
and then open that port range as well in your firewall.
22: ssh access
25, 587: smtp for exim to recieve email
53: dns (named), so your sites resolve. TCP and UDP here.
80, 443: apache traffic, http and https
110, 993: client pop email access 143, 995: clients imap email access
2222: DirectAdmin Access
3306: mysql acess. You don't need to open this port if you don't want to allow remote mysql access, as most mysql scripts are all accessed locally.